Original Paper
Correlation of Treatment Time and Ultrafiltration
Rate with Serum
Albumin
and C-Reactive Protein
Levels in Patients with End-Stage
Kidney Disease
Receiving Chronic Maintenance Hemodialysis:A
Cross-Sectional Study
Lajos Zsoma, Marianna Zsomb,
Tibor Fülöpa, Catherine Wellsa, Michael F. Flessnera,
József Ellerc, Charlotta Wollheimd, Jörgen Hegbrantd,
Giovanni F.M. Strippolid, e
a Division of Nephrology, Department of Medicine, University of Mississippi
Medical Center, Jackson, Miss. , USA;
b Diaverum Dialysis Center, Baja , and
c Department of Medical Informatics,
University of Szeged, Szeged , Hungary;
d Diaverum Medical Scientific Office, Lund , Sweden;
e Mario Negri Sud
Consortium, Chieti , Italy
Address of Corresponding Author
Blood Purif 2010;30:8-15 (DOI: 10.1159/000314648)
Key Words
C-reactive protein
Serum albumin
Hemodialysis
treatment time
Ultrafiltration rate
Abstract
Background: The relationship between treatment time, ultrafiltration rate
(UFR) and
inflammation has received limited exploration so far. Methods: This is a
cross-sectional
cohort study of 12 hemodialysis clinics. Statistical models explored the
association of
multiple patient- and dialysis-specific covariates with low albumin (≤40 g/l) or
high
C-reactive protein (CRP) (>5 mg/dl) and calculated the ORs and 95% CIs.
Results:
616 patients with a mean age of 60.9 ± 14.4 years participated in our study.
Mean treatment time was 237.3 ± 23.8 min and mean UFR was 7.0 ± 4.0 ml/kg/h. In
stepwise logistic regression, treatment time >4 h reduced the risk of low
albumin (OR
0.397, 95% CI 0.235–0.672, p < 0.001). Congestive heart failure (OR 1.634, 95%
CI
1.154–2.312, p = 0.006) and acute infection (OR 1.799, 95% CI 1.059–3.056, p =
0.03)
were significant correlates of the risk of high CRP. There was no association
between
UFR and either CRP or albumin. Conclusion: Treatment time had a
significant cross-
sectional association with serum albumin but not with CRP.
Copyright © 2010 S. Karger AG, Basel